… to 10 years treated with a combination of 2.5 g L-citrulline and 0.25 g metformin three times
a … , a randomized double-blinded placebo-controlled trial was conducted in another genetic …

… DMD therapy can be divided into approaches targeting dystrophin … a randomized double-blind
clinical trial on 47 ambulant DMD patients revealed that overall l-citrulline plus metformin …

… [26] (as a single and combined treatment with L-citrulline) … A recent single centre open label
study was conducted to … The phase II, double-blind, placebo-controlled study enrolled 51 …

… Duchenne Muscular Dystrophy (DMD) is the most common … in a single‐centre, randomized,
placebo‐controlled trial in … 2016) Treatment with l‐citrulline and metformin in Duchenne …

… Then, patients received both drugs at the same time, ie, 3 × 500 mg metformin + 3 × 5 g l-citrulline
for 6 weeks of treatment. Analogous, blood, and urine samples were collected …

… for the disease; however, the implementation of standards of care and … such as metformin
could be monitored by studying the … A follow-up double blind placebo controlled study was then …

… Therefore, metformin may be a possible beneficial therapeutic drug for the treatment of DMD
… -blinded, placebo-controlled trial with 186 patients. In this project, the patients were divided …

… , randomized, double-blind, placebo-controlled clinical trial … men treated using metformin,
or using metformin coupled with … , which are used to model Duchenne muscular dystrophy[63]. …

… GI dysfunction in Duchenne muscular dystrophy has been … Alternatively, administration of
L-citrulline, a dietary amino acid … clinical scores in patients with Becker muscular dystrophy. …

… Treatment with L-citrulline and metformin in duchenne muscular dystrophy: study
protocol for a singlecentre, randomised, placebo-controlled trial. …